phase

«Pfizer Inc.» Announced that terminates the study of the drug candidate, TRU-015, developed for the treatment of rheumatoid arthritis (RA) in collaboration with the biotechnology company «Trubion Pharmaceuticals Inc.». Decision «Pfizer» based on the preliminary results of phase IIb randomized, parallel, double-blind, placebo-controlled study to assess the efficacy and safety of two dosing regimens of the drug in combination with methotrexate in patients with RA, in which the TRU-015 did not reach the primary endpoint compared with placebo .
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This drug is well tolerated by patients, and serious side effects in the two groups took the drug were comparable with the group receiving placebo.

Commenting on this decision, senior vice president and chief medical director of «Trubion» Stromett Scott (Scott Stromatt) said that although the TRU-015 failed, now a drug company develops a new generation - SBI-087, which meets all required criteria.

Bin 49

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An absolute contraindication for administration of all vaccines is a strong reaction or complication to the previous introduction. By the strong reaction may include a significant increase in body temperature, infiltration of up to 8 cm in diameter. This is a contraindication due to the fact that children tend to progression of reactions to vaccination.
An absolute contraindication for administration of all live vaccines (BCG, BCG-M, OPV, measles, rubella and mumps) is that a child has a primary or secondary immunodeficiency, cancer, blood diseases. And also can not use live vaccines in pregnant women and persons on immunosuppressive therapy (hormone therapy, cytostatics).

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For the BCG vaccine and BCG-M contraindications (in addition to the above) are: the child's weight less than 2500 g and the presence of keloid scars, after earlier imposed by the vaccine.
From the introduction of DTP vaccine are exempt children with progressive disorders of the central nervous system (it can and tumors, and growing paralysis and paresis), as well as children are prone to afebrile seizures (epilepsy, for example). Ie when the convulsions the baby does not depend on the degree of temperature rise. Therefore possible to use DT and Td.
Vaccination against measles, rubella and epidparotita contraindicated in the presence of an allergic reaction to the quail protein and aminoglycosides.

Muscles of the press

Choose a weight with which you do 25 reps. Get on your knees facing the block device, grasp the handle of the block and start to pull it down while bending to the floor. Muscles of the press should be in constant tension. Slowly return to starting position.

Side "twisting"
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Objective: To study the upper part of the press.

This is a great way to "narrow" waist! Lie down sideways on the bench, so that part of the body above the waist appeared over the edge, and you can freely bend the body up and down. Ask someone to hold your feet during exercise. Bending at the waist, slowly sank into the bottom position and just as slowly climb to the starting position.

Valentine's Day

As it was nice in the last month of winter to meet spring holiday - Valentine's Day!

Why spring? Because the love and spring seem to be inseparable. And let the outside still sweeps the snow, but in the morning on a white sheet of snow drops the dawn glare, so similar to the red hearts and red roses petals ... And my heart is in a special light and heat, and silver reed pipe Bullfinch seems no less melodic and caressing ear than the nightingale.



They say that the first "Valentine" - a love postcard - wrote to his sweetheart in the III century in Rome, a Catholic priest Valentine, unjustly condemned to death a cruel emperor Claudius for wedding lovers. So whether it was really, nobody knows, but pretty sad story is not one century is deeply touches the hearts of lovers around the world.



And the Russians also did not mark the first year of this romantic holiday, sending sweet "Valentine" with the image of hearts, kissing angels and doves, rozochek, rabbits, cats and dogs. Rarely there is a girl or woman who was no joy, it would seem, is absolutely useless gift from a loved one in a modest bouquet of flowers, a teddy bear heart or funny. It inspires so romantic! And not only young, but mature people, bringing into our lives something so we all need - attention, care, tenderness, touching declaration of love ...



Can not be happy without love, whether you're a wise man, a warrior, the president or the janitor. Therefore, even the busiest people in this day remember their second halves, and even the poorest are preparing for favorite gift ... a modest but heartfelt. After all, in essence, the very "Valentine", and a gift can be their own hands, would love and desire to please the man she loved. There are lots of ways! "Valentine" can draw, make in the form of application of colored paper, embroidered, tie hook, cut it out of wood ...



Different countries have their own tradition of celebrating Valentine's Day and delivery

love letter. For example, in Italy, "Valentine" is sent by mail in the envelope of pink paper, sealed with a kiss, and often with no return address. And in Spain, especially romantic admirers send "Valentine" with a pigeon. In the United States on the houses hang beautifully decorated pink paper and foil mailboxes specifically for "valentines".



Pink on this day plays a major role, personifying a touching romantic tenderness. Not only paper for gifts, but also the background of "valentines", ribbons, candles, etc. must be pink. For those couples who are in close relationships, such as a long-standing mistress, or wife, experts recommend to give this day a pink underwear, as if to sex did not happen, then you can give a pink scarf, belt, ornament pink.



Of the colors the most vivid and outspoken symbol of love are roses. Now, at any time of year you can buy a rose of any color. So what kind of gift? It depends on what you want to say his favorite ...



Pink rose shows tremulous tenderness men, that he loves his girl and admires her. And that he - a great romantic.

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Red Rose - declaration of love. It may also say that a man covered sensual passion that burns not only his heart but his body, and he wants everything and right now.



Bordeaux Rose reports that the man was determined, ready to make an offer and lead the beloved to the altar.



Say that it was Valentine's Day birds start looking for a pair for breeding. Pigeons in fact really is coo. And the winter they make trouble.



Good to meet St. Valentine's Day together, if you already have a couple. You can, of course, go on a romantic journey to exotic destinations ... but no less romantic and grandmother's house in the village in a snowy garden, and the usual summer residence. Apartment in the city, too, can turn to the abode of love, if some try to, for example, hung a garland of pink ribbons and velvet hearts, the bed on the table, pink satin or silk cloth, place the candles, bowls of fruit, a plate with the apples, cut in half.



The best drink in the day will be champagne. Although, of course, have to navigate around on your own taste.

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Probably, most of the girls come into raptures when beloved by candlelight will read their poems about love. It's so romantic and touching.



Those who have not got a half a second, you can guess and make a wish to bring a loved one. To this end the night with 13 on 14 February to wash with water from the tap, comb hair, put under the pillow "Valentine" before going to bed and say: "On the day of Valentine's call the second half." And imagine the image of the desired lover. In the morning, "Valentine" to put in a secret place, for example, to hide in the closet or dresser between his underwear.



For the love spell rich lover should own draw goldfinches and hang their creations on the wall above the desk or over the bed, so you can often seen as an image. If you want beautiful, romantic, but not non-binding relations, draw Bullfinch. And if the dream is a faithful lover, love at first sight and for life, the need to draw a swan.



Despite the fact that Valentine's Day - Valentine's Day, that is, people who already have a pair, it does not mean that everyone else should stay at home, indulging in melancholy.



Instead, you need to go to the guests at the party, in a cafe in the park. There where a lot of people, where you can not just fun, but also to get acquainted with his future "Valentine" or "Valentine". It is precisely because, seemingly random encounters often grow deep and serious relationship leading to marriage.



Nowadays, in many countries around the world on February 14 is the day romantic dating, confessions of love and ... weddings.



So love and be loved!

15m time span

With all this warm, that she herself is from? This 10 - 15-minute time span during which the organism is prepared for the physical strain. Some want to instantly get results, turn out to warm up and deal with no apparent problems. But such carelessness leads to pain and injury, as well as to perform the exercises are not ready, not only muscles but also the nervous system. Psychologically, you have not yet tuned to perform the selected exercises, so you should talk a little about the importance of warming up.



The idea is that the heated muscle can be safely stretched to larger amplitude motions than cold. Thus, you become more flexible, and with it can minimize the damage that may occur by chance: in case of error or if you suddenly stumble.



You can add that free and flexible body reacts quickly and amortizes accidental falls and awkward position, which can not be excluded during the execution of a complex exercise. In summary, it may be noted that the warming is not causing early fatigue, prepares the body to an active training and helps prevent injuries. Moreover, it gives energy and makes physical education enjoyable and fun!



How does the proper warm-up on our body?

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- It helps psychologically tuned for the next load and gives the opportunity to feel the mobility of the joints;

- Increases heart rate (HR) and blood flow to the muscles, that is, prepares the cardiovascular and muscular systems to training;

- Produces heat in the muscles and tissues of articulated, which makes them more flexible and resistant to damage.



So how do you warm up?



Warm-up usually includes general and special parts. General warm-up consists of three parts. The first includes simple pandiculation in place that help to feel the movement. The second part - it exercises on different muscle groups, usually light jogging jogging. These exercises are designed to control the growth of heart rate during the temperature increase muscles. The third part involves a static streyching, which is performed much more intense and more energetic than the original banner in the first part. Muscles should warm up slowly and steadily during 15 - 30 sec. until the discomfort, but no pain.



Special warm-up consists of exercises related to the sport that you have gathered to do. For example, if you decide to run, you first need to run a mile in a leisurely pace, and then only gradually accelerate to a given training mode speed. In this case, the body will be able to consistently adapt to specific stresses of training.



There is a representation that the workout is done only to the aerobics. False: Warm up is important in all sports! The concepts of general and specific warm-ups are treated as running and jumping, as well as for swimming and cycling, as in tennis and volleyball, as well as to weightlifting and other sports.



Well if you will warm up your habit. It's so great to feel confident in their abilities, to be protected for sure, with only a small amount of workout time!

rules at work

Rules of conduct in the office include the following components - communication with colleagues, leadership and customers, the implementation of their direct duties, compliance with regulations of working hours and corporate standards. The main rule of conduct - punctuality in all things. Only diligent and accurate employee will be able in time to perform the work. These qualities characterize him as a man who can be relied upon. Lateness at work is strictly prohibited in virtually all companies.



Possession basics Half-menezhmenta help the employee perform work on time.

The second rule of conduct - strict adherence to corporate standards. Every self-respecting company's existing corporate book, which specifically and clearly defined all the rules of conduct in different situations. When hiring staff familiar with the contents of this unique document under the painting. Compliance with corporate and commercial secrets of the company - the holy of holies. This includes any information about the company: from staff and technology to economic performance of the corporation.



The third rule of conduct - compliance with a certain dress code of the company. Each corporation has its own proprietary standards for the appearance of staff. If this is not mentioned separately, the appearance of employees must conform to generally accepted business style. Tight clothes, neat hair, personal hygiene.

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The following rules shall provide employees the culture of communication with colleagues, management and customers. In the corporate books are usually described in detail the speech modules, and standards of communication. For example, the rules of admission of clients and visitors are welcome from the description, the basic rules of hospitality, comfort and create an environment of trust, identifying needs of the client and the motive of his visit, regulate the flow of visitors, the rules of supply of coffee and tea, etiquette when dealing with retirees and the disabled, ie, the entire arsenal of etiquette in communication with the client.



In communicating with employees and superiors rules of conduct based on trust, respect and teamwork. The ability to prevent conflict in the team and competently to withdraw from it in case of - the cornerstone of positive communication. One of the rules of conduct in the office says - do not bother to colleagues in their work. Idle talk does not relate to the working process, gossip, discussion and condemnation of the management and staff in the office are not allowed.



Rules of Conduct provide knowledge of business talks and participation in corporate events. Moderation and ethics - the perfect companion in such situations. Literate and concise telephone calls - a sign of professionalism. Business writing skills, etiquette and protocol - all of these cornerstone of business communications as well contain a set of rules. Knowledge of etiquette and taboos tolerances helps to fulfill professional responsibilities in quality.



Rules of conduct in office adheres strictly to the regulations of the selected company. If lunch is provided strictly by the hour, snacks, and smoking breaks during working time are considered mauvais ton. Culinary scents and food debris on desktops outside normal hours can damage the image of the enterprise. Free mode of labor can be selected by the basis of this right to corporations, but employees should know about it beforehand.



Appeal to colleagues, managers and visitors by name and patronymic - a unique feature of the rules of conduct in Russia's office. Historically, the roots of such treatment go back to the traditions of the Russian people. In dealing with business partners from abroad, provided treatment only on behalf of or with an indication of the San and regalia. Knowledge of business - etiquette as an integral component of the rules of business conduct.



The friendly atmosphere in the team will take possession of all the rules of conduct beginner. The main thing - do not hesitate to ask for and carefully observe what is happening. Openness to contact and professionalism will help to quickly learn the inner working schedule and understand the role and status of staff.